Medicine_CHIP

Here are some notes for basic medicine knowledge that would help me understand the medicine problem itself. This page specific to CHIP (Clonal hematopoiesis of indeterminate potential).

Clonal hematopoiesis refer to a population of related myeloid cells with an acquired gene mutation. It is a characteristic of myelodysplastic syndromes, but may also be found in some individuals who have no detectable hematologic malignancy, here it refers to clonal hematopoiesis of indeterminate potential (CHIP). There are four different kinds of clonal hematopoiesis: CHIP with driver mutation; CHIP with unkown drivers; chromosomal mosaicism; somatic loss of Y chromosome. Mosaicism is the possession of multiple genetically different cell lines in a single person that a person has 2 or more genetically different sets of cells in his or her body. A person with mosaicism may have some cells in his or her body with 46 chromosomes, but other cells have 47 chromosomes. It might be caused by an error in mitosis. Mitosis continues thoughout the lifetime and if there is an error that a cell does not split into 2 cells, the result is that some cells have the normal number of 46 chromosomes and other have more or fewer chromosomes.